Dissecting intrinsic chaperonin activity
نویسندگان
چکیده
منابع مشابه
Dissecting intrinsic chaperonin activity.
It has long been known that the linear sequence of amino acids along the polypeptide chains contains all the necessary information required to determine the correct three-dimensional structure of a protein (1). Indeed, a large number of proteins have been shown to refold spontaneously in vitro from an unfolded denatured state to the native folded state (2–6). Other proteins, often large ones, h...
متن کاملChaperonin activity modulates codon adaptation
1 Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada, 2 Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada and 4 Department of Computer Science, University of Toronto, Toronto, Ontario, Canada * Correspon...
متن کاملMacrophage antiviral activity: extrinsic versus intrinsic activity.
Peritoneal exudate cells from strains of mice both resistant and susceptible to challenge with mouse hepatitis virus strain JHM were examined for extrinsic and intrinsic antiviral activity. Thioglycolate-elicited and resident peritoneal cells from uninfected mice were able to suppress viral growth in a permissive cell. The active cell in both populations is an adherent, radiation-resistant, Thy...
متن کاملBardet-Biedl Syndrome as a Chaperonopathy: Dissecting the Major Role of Chaperonin-Like BBS Proteins (BBS6-BBS10-BBS12)
Bardet-Biedl syndrome (BBS) is a rare genetic disorder that belongs to the group of ciliopathies, defined as diseases caused by defects in cilia structure and/or function. The six diagnostic features considered for this syndrome include retinal dystrophy, obesity, polydactyly, cognitive impairment and renal and urogenital anomalies. Furthermore, three of the 21 genes currently known to be invol...
متن کاملDissecting toxin immunity in virus-infected killer yeast uncovers an intrinsic strategy of self-protection.
Toxin-secreting "killer" yeasts were initially identified >40 years ago in Saccharomyces cerevisiae strains infected with a double-stranded RNA "killer" virus. Despite extensive research conducted on yeast killer toxins, the mechanism of protecting immunity by which toxin-producing cells evade the lethal activities of these proteins has remained elusive. Here, we identify the mechanism leading ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1997
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.94.1.7